KNOW QUALITY OF YOUR SILYMARIN:
Silymarin (Milk Thistle) in natural form is poorly absorbed by the body to offer any clinical benefits. It must be modified and reformulated to make it bioavailable, a significant challenge in the manufacture of an effective product. The products vary widely in efficacy.
Samarin®, manufactured with proprietary technology, is a highly bioavailable.
KNOW THE QUALITY OF YOUR SILYMARIN
SILYMARIN’S POOR SOLUBILITY
Silymarin taken orally takes many hours for the body to absorb in the gastrointestinal tract, and a lot of it is excreted out in bile and urine in the meanwhile. In its natural form, Silymarin cannot clinically deliver health benefits.
IMPROVING SILYMARIN’S BIOAVAILABILITY
Manufacturers have developed proprietary and patented formulations and techniques to convert silymarin’s active compounds (silybin A & B) into highly absorbable forms.
The methods include combining isolated silybin with other molecules; encasing it into the structure of another molecule and safely delivering it to target liver cells; converting it into soluble derivatives; breaking silybin into “nano” particles. These techniques can increase silybin’s bioavailability 3 to 30 times the natural form, depending on the reformulation and the delivery mechanism.
The higher the bioavailability, the lower the dose required to obtain therapeutic value.
HOW TO TELL HOW GOOD IS YOUR SILYMARIN?
Not all techniques and reformulations can achieve the desired results. As a result, Silymarin products in the market vary widely in solubility and bioavailability. Only lab tests can tell how good is the silymarin product.
The acceptable standards for testing solubility are well established in the U.S. Pharmacopeia (USP) and the British Pharmacopeia (BP).
THE RIGHT TEST METHOD IS ALSO IMPORTANT
HPLC (high-performance liquid chromatography) is more accurate than the less sensitive UV (Ultraviolet) Spectroscopy, which can exaggerate the solubility measure.
Samarin® efficacy is measured using HPLC. Each batch is tested before it is released to the consumer.
The solubility and bioavailability facts are generally not mentioned on the product label. It is up to the consumer to inquire about these critical measures of quality, including the test method used to analyze the product.
Facts about the brand*
- Samarin® contains pharmaceutical-grade of Silymarin/Milk Thistle manufactured at a European GMP facility.
- Samarin® has been tested by an independent lab showing its soluble silymarin content is on average 105.8% of the product's label claim, in compliance with US Pharmacopoeia (USP 38) specifications.
- Samarin® has been tested by an independent lab demonstrating it dissolves twice the rate of some leading brands.
- Samarin has been tested by an independent lab confirming that 98.5% to 101.5% of the label amount of the active ingredients dissolves in 45 minutes, significantly higher than the 75% minimum established as the US Pharmacopoeia's most recent standard (USP 38).
All tests of product quality were performed with HPLC and in accordance with standardized test methods.
‡These statements have not been evaluated by the US FDA
*Product statements have not been approved by the US FDA. The product is not intended to treat, cure or prevent disease.
DISCLAIMER: The information offered should not be construed as medical advice; please consult your doctor before taking Silymarin, and nothing you have read here should cause you to delay seeking medical advice.