Samarin® is highly soluble and bioavailable form of Silymarin, also known as Milk Thistle, which in natural form is largely insoluble and is not absorbed well in the body.
Samarin® contains pharmaceutical-grade, proprietary formulation of bio-active components isolated from European Silymarin.
Natural Silymarin is Poorly Absorbed
The natural form of Silymarin when administered is largely excreted out in bile and urine, and does not deliver health benefits. “Although it has been proved by clinical trials that silymarin is safe at high doses (>1500 mg/day) in humans, pharmacokinetic studies revealed poor absorption, rapid metabolism, and ultimately poor oral bioavailability of silymarin (Javed et al., 2011, p. 239).” (Phytonanoconjugates in oral medicine L. Bharathi Priya, ... V. Vijaya Padma, in Nanostructures for Oral Medicine, 2017)
Overcoming the Challenge of Poor Bioavailability
Silibinin is poorly absorbed and efforts to improve its bioavailability have been only partially successful. In both animal models and humans, the bioavailability of silibinin ranges from 20% to 50% following oral administration. Chemical complexation with phosphatidylcholine (forming silipide) greatly increases the lipophilic properties of silibinin and hence improves its bioavailability.
Oral administration of silipide formulations result in plasma silibinin concentrations that are several-fold higher than those achieved with standard silibinin (i.e., the mixture of any number of these constituents) or silymarin preparations in equimolar dosages (i.e., those doses that ideally have the same amount of silibinin) and overall enhanced bioavailability. Absorption is fairly rapid, with peak plasma concentrations (Cmax) reached in approximately 2 to 4 hours (Tmax).” (Clinical Studies of Silymarin/ Clinical Pharmacokinetics of Silymarin: John Markowitz, Pharm. D., Associate Professor, Department of Pharmaceutical Sciences, Laboratory of Drug Disposition and Pharmacogenetics, Medical University of South Carolina, Charleston, SC.)
Reformulations of bioactive components of Silymarin may not result in similar plasma concentrations and bioavailability between products, as they vary from manufacturer to manufacturer. Chemical complexation and the manufacturing process are jealously guarded by manufacturers.
Dissolution test for solubility comparison between Samarin® and a leading originator brand*
Samarin® showed solubility and dissolution of more than 90% at the 10th minute and remained at that level for a period of 60 minutes, compared with the competing brand’s 45.6% at the 10th minute and 67.5% through the 60-minutes test period.
- Reached maximum blood level in 1.5 hours
- Metabolized in the liver
- Mainly excreted in the bile
- Elimination half-life : 6 to 8 hours
Samarin® Recommended Dose & Administration
- Initial dose in severe cases: 140 mg three times daily
- Maintenance dose: 140 mg twice daily
- No dose adjustment in mild-to-moderate renal impairment
Facts about the brand*
‡These statements have not been evaluated by the US FDA
*Product statements have not been approved by the US FDA. The product is not intended to treat, cure or prevent disease.
DISCLAIMER: The information offered should not be construed as medical advice; please consult your doctor before taking Silymarin, and nothing you have read here should cause you to delay seeking medical advice.